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DRUG SPOTLIGHT – HALOPERIDOL

April 9, 2013

New Drug Approvals

File:Haloperidol.svg

HALOPERIDOL

CAS No:- [52-86-8]

IUPAC Name:- 4-[4-(4-Chlorophenyl)-4-hydroxy-1-piperidinyl]-1-(4-fluorophenyl)-1-butanone

MW: 375.86, C21H23ClFNO2

Drug information:- Haloperidol is an anti-psychotic drug. This butyrophenone compound is used for the treatment of schizophrenia and other psychotic disorders in adults and childrens.

Haloperidol was discovered by Paul Janssen. It was developed in 1958 at the Belgian company Janssen Pharmaceutica and submitted to the first of clinical trials in Belgium later that year.

Haloperidol was approved by the U.S. Food and Drug Administration (FDA) on April 12, 1967; it was later marketed in the U.S. and other countries under the brand name Haldol by McNeil Laboratories.

Haloperidol is a dopamine inverse agonist of the typical antipsychotic class of medications. It is a butyrophenone derivative and has pharmacological effects similar to the phenothiazines.

Haloperidol is an older antipsychotic used in the treatment of schizophrenia and acutepsychotic states and delirium. A long-acting decanoate ester is used as an injection given every four weeks to people with schizophrenia or related illnesses who have poor adherence to medication regimens and suffer frequent relapses…

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