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March 11, 2013

New Drug Approvals

Quarfloxin, CX-3543

Molecular Formula: C35H33FN6O3

cas no 865311-47-3

Molecular Formula: 604.67

SAN DIEGO, March 6, 2013

Cylene Pharmaceuticals, Inc. announced today that it has entered into an exclusive, worldwide Option and License Agreement that will allow TetraGene LLC to advance the development of Quarfloxin and Cylene’s associated anticancer quadruplex-targeting technologies. Cylene will receive an upfront fee, as well as potential milestone payments and royalties on product sales for the exclusive license.

TetraGene is developing small molecule drugs aimed at highly validated cancer-causing genes, by directly targeting G-quadruplex structures in genomic DNA. TetraGene has the option to acquire worldwide rights to the technologies licensed from Cylene, which include the Phase II compound Quarfloxin and several registered patents. Quarfloxin has been demonstrated to be safe and well-tolerated in Phase I clinical trials.

“This agreement is a clear win for both organizations,” stated William G. Rice, PhD, President and CEO of Cylene Pharmaceuticals…

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