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March 7, 2013

New Drug Approvals

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has a fluoro gp

WO-2004016086, feb2004

2,4,5-Trisubstituted imidazoles and their use as anti-microbial agents

WO-2006126177, nov 2006

WO-2010102393, sept 2010

Description of LOR-253, LT253: LOR-253 HCl is the hydrochloride salt of a small molecule inhibitor of human metal-regulatory transcription factor 1 (MTF-1) with potential antitumor activity. MTF-1 inhibitor LOR-253 inhibits MTF-1 activity and thereby induces the expression of MTF-1 dependent tumor suppressor factor Kruppel like factor 4 (KLF4). This subsequently leads to the downregulation of cyclin D1, blocking cell cycle progression and proliferation. This agent also causes decreased expression of genes involved in tumor hypoxia and angiogenesis.

Lorus Therapeutics Inc.

http://clinicaltrials.gov/ct2/show/NCT01281592

ClinicalTrials.gov Identifier: NCT01281592

Lorus Therapeutics

This is an open-label, phase 1 study to determine the maximum tolerated dose (MTD) or appropriate target dose if MTD not reached to identify the recommended phase 2 dose of LOR-253 HCl in patients with advanced or metastatic solid tumours.

March 5, 2013) – Lorus Therapeutics Inc. …

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